The mortality rate following infection by C perfringens bacteremia is extremely high (ranging from 27% to 80%) and disease progression is rapid.[2,6–8] The median time from onset to death from C perfringens bacteremia is approximately 8 to 9.7 hours.[2,8] Therefore, untimely and inappropriate therapy for C perfringens may lead to multiple organ failure or death within a short period of time.[9] Notably, BSI is usually manifested by elevated inflammatory markers, such as leukocytes, CRP, and procalcitonin. Here, CRP is linked to Multiple Organ Failure.