CDH1 and renal pelvis/ureter urothelial carcinoma: As mentioned above, E-cadherin was first revealed to be an independent marker in a subsequent multivariate analysis in 2005.[37] Conversely, most of the studies published thereafter with larger cohorts failed to demonstrate an independent association between E-cadherin expression and UTUC prognosis after surgery.[10,34,38,40] Although the patients with UTUC had pathophysiology similar to that in patients with UBC, the reason for the current meta-analysis results is presumed as follows.