The hazard ratios (HRs) were as follows: lymph node positive (HR = 3.011), histological grade (HR = 2.340), HIF-1α positive expression (HR = 2.027), TNM stage III (HR = 1.632), c-myc-positive expression (HR = 1.514), tumor size > 2 cm (HR = 1.465). Here, HIF1A is linked to neoplasm.