Some literatures have reported that HIF-1α was highly expressed in many tumors including breast cancer, which may be involved in the process of apoptosis, proliferation, migration, invasion, and neovascularization of tumor cells.[15,16] As a transcription factor of tumor cells against hypoxic environmental stress, HIF-1α could regulate a variety of downstream genes, thereby increasing the invasive ability of tumors and increasing the resistance of tumors to external treatment.[17,18] It may be the reason that TNBC was not sensitive to radiotherapy and chemotherapy. The gene discussed is HIF1A; the disease is breast cancer.