Additionally, a high level of fibrinogen was closely correlated with advanced tumor stage (OR = 2.14, 95% CI: 1.83–2.50, P < .001), lymph node metastasis (OR = 1.81, 95% CI: 1.56–2.11, P < .001), distant metastasis (OR = 1.48, 95% CI: 1.12–1.94, P = .005), deeper tumor invasion (OR = 2.25, 95% CI: 1.47–3.45, P < .001) and high carcinoembryonic antigen (OR = 1.41, 95% CI: 1.18–1.68, P < .001). The gene discussed is CEACAM5; the disease is neoplasm.