CCND1 and renal carcinoma: Wu et al showed that PVT1 inhibited renal cancer cell apoptosis by enhancing the stability of Myeloid cell leukemia-1 mRNA.[43] Li et al revealed that the expression of PVT1 was up-regulated in ccRCC tissues, and knockdown of PVT1 induced apoptosis by increasing the expression of poly ADP ribose polymerase and Bcl-2-associated X protein, and promoted cell cycle arrest at the G1 phase by decreasing the expression of cyclin D1.