RGN and chronic hepatitis: In addition, we have shown differing serum regucalcinconcentrations between healthy controls and patients with chronic hepatitis or ACLF,indicating that serum regucalcin concentration is related to the severity of liverinjury, and may represent a superior biomarker for liver injury to ALT.Specifically, a serum regucalcin concentration higher than 2.42 ng/mL indicated thepossibility of liver injury, and a concentration higher than 4.26 ng/mL impliedliver failure.