RNF103 and childhood onset asthma: The novel loci included SNPs in or near the DENND1B (DENN domain containing 1B) gene, which has been implicated in childhood asthma (Sleiman et al., 2010); RNF103 (ring finger protein 103), a suspected antidepressant target (Yamada et al., 2000) and genes related to axon guidance (DCC netrin 1 receptor) (Kolodziej et al., 1996).