Recently, it was reported that TLR5 was associated with tumour growth and metastasis,27 and TLR5 expression was positively related with allo‐transplant rejection in our previously study.24 Considering of TLR5 expressed on NK cells within breast cancer reported by other research28 and TLR5 expression is able to restrain tumour growth and metastasis both in vitro and in vivo,29 we postulated that TLR5 on TNBC cells may play an important role in TNBC progression, which may be a new target suitable for diagnosis and targeted therapy for TNBC. This evidence concerns the gene TLR5 and neoplasm.