AKT1 and Sepsis: According to some studies, the PI3K/Akt pathway is not only a crucial regulatory molecule for various cellular functions, but also important in transduction signalling underlying endothelial barrier function during sepsis.50, 51, 52, 53 In the present study, we found that SV/SV‐NPs activated the PI3K/Akt pathway and promoted Akt phosphorylation, which was inhibited by LPS.