The IL‐6 signalling pathway was significantly increased in endometrial stromal cells after in vitro coculture with macrophage in adenomyosis which might play a role in the formation of ectopic tissues in adenomyosis.25 The ERK/MAPK signalling pathway was associated with the proliferation of uterine smooth muscle cells in the women with adenomyosis.26 The overlapping of our findings with the previous studies may reflect the universal mechanisms underlying the adenomyosis and the reliability of our data. This evidence concerns the gene IL6 and adenomyosis.