TP53 and colorectal carcinoma: In colorectal cancer (CRC), AURKB has also been shown to act as an important oncogenic factor, be involved in the development of CRC, and promoted drug resistance and progression of CRC though regulation of the Wnt signaling pathway and the p53-related pathway (Subramaniyan, Kumar & Mathan, 2017; Nair et al., 2009; Wu et al., 2011; Pohl et al., 2011).