TF and cancer: An accumulating genome-wide association study (GWAS) shows that the mutations of TFs or TF-binding sites are closely related to many human cancers (reviewed in Deplancke, Alpern & Gardeux, 2016), such as gastric cancer (Yin et al., 2017), liver cancer (Cao et al., 2017a; Cao et al., 2017b), prostate cancer, colorectal cancer (Saijo et al., 2016) and breast (Humphries et al., 2017) cancer.