This study analyzed the survival of a large cohort of patients with IBC based on the SEER database and confirmed eight independent prognostic factors including race, M stage, surgical modality, CT status, tumor size, ER, PR and Her-2 status, based on the nomogram which will provide the first comprehensive evaluation profile to help physicians make a reasonable treatment decision and estimate prognosis in IBC patients. The gene discussed is ESR1; the disease is inflammatory breast carcinoma.