For example, mutations in ASXL1 and ASXL2 occur at a high frequency in AML with t(8;21)(q22;q22.1) but are absent in AML with an inv(16)(p13.1q22) implying that they selectively cooperate with AML1-ETO [11–13]. The gene discussed is RUNX1; the disease is acute myeloid leukemia.