BRCC3 and acute myeloid leukemia: In order to analyze whether loss of BRCC3 affects cell growth, we determined the effect of CRISPR/Cas9-mediated BRCC3 inactivation in the two AML cell lines with t(8;21)(q22;q22.1) Kasumi-1 and SKNO-1 and in the OCI-AML5 cell line without t(8;21)(q22;q22.1).