Under diabetes-like conditions (exposure to advanced glycation products (AGE)), Saa and inflammatory mediators, such as C-X-C motif chemokine ligand 5 (Cxcl5), C-C motif chemokine ligand 2 (Ccl2), and C-C motif chemokine ligand 5 (Ccl5) were significantly upregulated in renal podocytes47. Here, SAA1 is linked to diabetes mellitus.