Similarly, renal fibrosis was increased in all kl/kl mice (Fig. 1I) and mRNA expression of markers of fibrogenesis such as Timp1, Col1a2 and Fn1 were elevated in kl/kl kidneys independently of the presence of FGFR4 (Fig. 1J). The gene discussed is FGFR4; the disease is renal fibrosis.