For instance, the feedings on Mudgo rice resulted in the downregulation of two insulin signaling (ILS) players, insulin receptor 2 (InR) (NLU017789.1) and tumor-necrosis factor receptor-associated factor 5 (TNF5) (NLU005471.1) in the TN1-BPH. This evidence concerns the gene INS and benign prostatic hyperplasia.