All these analyses and comparisons are important to assess the suitability of LAAs and HLA-I epitopes as immunotherapeutic targets in leukemia, which should contain epitopes with high affinity for HLA, be highly immunogenic for induction of tumor-specific CD8 T cells, and be highly interconnected with essential pathways so that they cannot be down-regulated without damage to vital processes. This evidence concerns the gene CD8A and leukemia.