DNMT3A and Tatton-Brown-Rahman overgrowth syndrome: Supporting this, missense mutations affecting the PWWP domain of DNMT3A are also reported in Tatton-Brown–Rahman syndrome which similarly abrogate its ability to bind H3K36me2 and H3K36me3 in vitro, but contrastingly manifest overgrowth and DNA hypomethylation similar to that observed in Sotos syndrome (Weinberg et al., 2019).