In β-catenin-driven HCC, CTNNB1 mutations are generally ubiquitous within each tumor (Torrecilla et al., 2017), but nuclear and cytoplasmic localization of β-catenin is heterogeneous in both animal models (Evason et al., 2015; Qiao et al., 2018) and patients (Friemel et al., 2015; Rebouissou et al., 2016). Here, CTNNB1 is linked to hepatocellular carcinoma.