It seems that neither the Atox1 nor CCS gene are often mutated in any of the cancers examined, with the highest mutation frequency for CCS and Atox1 observed in uterine corpus endometrial carcinoma (UCEC) (1.5%) and liver hepatocellular carcinoma (LIHC) (0.27%) malignancies, respectively (Fig. 9A). Here, CCS is linked to cancer.