INS and metabolic disease: Szkudelski and Szkudelska [1013] gave an overview of the role of resveratrol in diabetes from animal models to human studies; in particular, the authors summarized the effect of resveratrol reported in animals models: improvement of glucose homeostasis, decrease of insulin resistance, protection of pancreatic β cells, improvement of insulin secretion, and amelioration of metabolic disorders [1013].