However, T2DM patients with pancreatic exhaustion (FPG 152 ± 46 mg/dL; fasting plasma insulin 16 ± 8 μU/mL; n = 8), treated as above, showed a significant increase in pancreatic β-cell function in response to glucose loading (insulin AUC increased from 51 ± 29 to 98 ± 20 μU/mL/h, p < 0.0001), paralleled by a C-peptide AUC increase from 7.2 ± 2.8 to 13.7 ± 6.8 (p < 0.0001). Here, INS is linked to type 2 diabetes mellitus.