AKT1 and neoplasm: The main enriched pathways known to contribute to tumor progression and survival are reported in Figure 3B. Among them we observed the FoxO signaling pathway, which is involved in both treatment response and resistance acquisition [14], and the PI3K-Akt signaling pathway, which exerts relevant functions in cell proliferation and can be triggered both by neutrophins, growth factors required for the development of sympathetic neurons [15], and by integrins, components of focal adhesion structures mediating the signals between extracellular matrix (ECM) and interacting cells [16].