Gene expression and Chromatin ImmunoPrecipitation followed by sequencing (ChIP-Seq) analysis illustrated that the binding affinity of EBNA2-associated protein complexes to the SLE-risk loci can be altered by the SLE variants, which eventually lead to the regulation of nearby genes such as IKZF2, CLEC16A, BLK, MIR3142 and HLA-DQB1 in an allele-specific manner [105]. This evidence concerns the gene IKZF2 and systemic lupus erythematosus.