FCGR2B and systemic lupus erythematosus: With reference to the discussion of affinity B cell selection in the germinal centers in Section 1.3, a recent study advocated the pathogenic potential of a lupus-susceptible hypofunctional polymorphism (Ile232Thr) of FcγRIIb in reducing apoptosis of germinal center light-zone B cells and affinity maturation without affecting the follicular helper T cells in the FcγRIIb232Thr/Thr mouse model [30].