HLA-DRB1 and systemic lupus erythematosus: On the other hand, in European SLE studies, the excess risk of SLE was apparently conferred by HLA-DRB1*03:01, HLA-DRB1*08:01, HLA-DQA1*01:02 and two MHC SNPs [93] or HLA-B*08:01, HLA-B*18:01, HLADQB1*02:01, HLA-DRB3*02:00 and HLA-DQA*01:02 and the class III SNP rs74290525 [51].