Of the 53 SLE GWAS loci which were identified in European population, less than 26 were bound by EBNA2 and other co-occupying transcription factors, especially NF-κB proteins such as RELA, RELB, REL, NFKB1 and NFKB2, forming the so-called super-enhancers [105]. This evidence concerns the gene NFKB1 and systemic lupus erythematosus.