The SWD1 ortholog, RBBP5, which was UES with gemcitabine in lung tissue (Additional File 8, File C; 1-0-4), is upregulated in self-renewing cancer stem cells in glioblastoma and necessary for their self-renewal, is involved in the epithelial-mesenchymal transition in prostate cancer cells via its role in H3K4 trimethylation, and is upregulated in hepatocellular carcinoma [232,233,234,235]. This evidence concerns the gene RBBP5 and Familial prostate cancer.