LCB4/5 homologs that were UES in PharmacoDB included: (1) CERKL (Additional File 8, Files B–C; 1-0-6), a ceramide kinase-like gene that regulates autophagy by stabilizing SIRT1 [264], a gene mentioned above for its inhibition being synergistic with cytarabine against acute lymphoblastic leukemia cells [138], and (2) AGK, which is overexpressed in hepatocellular carcinoma, glioma, breast, and cervical squamous cell cancers [265,266,267,268]. Here, SIRT1 is linked to acute lymphoblastic leukemia.