Although not UES in PharmacoDB, inhibition of the HST1 homolog, SIRT1, by Tenovin-6 inhibits the growth of acute lymphoblastic leukemia cells and enhances cytarabine cytotoxicity [138], enhances gemcitabine efficacy in pancreatic cancer cell lines, and improves survival in a pancreatic cancer mouse model [139]. This evidence concerns the gene SIRT1 and familial pancreatic carcinoma.