BECN1 and cancer: Other genes involved in autophagy-related processes that had human homologs UES in cancer cell lines included: (1) PEP12/STX12 (Figure 6D; 1-0-10), a t-SNARE required for mitophagy [180], for which underexpression is associated with risk of recurrence [181]; and (2) VPS30/BECN1, knockdown of which enhances gemcitabine cytotoxicity in pancreatic cancer stem cells [170].