Human homologs of ACB1 exhibiting UES (Figure 5C; 2-0.16-1) included: (1) DBI, which is upregulated in hepatocellular carcinoma and lung cancer, and its expression is negatively associated with multidrug resistance in breast cancer [101,102,103]; (2) ACBD4, which promotes ER-peroxisome associations [98] and is upregulated by a histone deacetylase inhibitor, valproic acid, in a panel of cancer cell lines [99]; and (3) ACBD5, which also promotes ER-peroxisome associations, but its link to cancer is unclear [100]. The gene discussed is ACBD5; the disease is cancer.