SOCS3 and infection: While the expressions of STAT3 target genes exhibited a more complicated pattern, despite the immediate decreases of SOCS3, IL21, IL17A and CEBPD from the beginning of the infection (Figure 2A), CXCL10, IL10, IL1B, IL6 and CCL2 exhibited increased expressions during the early infection, and then decreased at 24 hpi (Figure 2C–G).