In contrast, SATB2-AS1 suppresses colorectal cancer (CRC) progression by acting as a scaffold to recruit protein p300, whose acetylation of H3K27 and H3K9 at the SATB2 promoter to upregulate the expression of SATB2, a suppressor of CRC growth and metastasis. The gene discussed is EP300; the disease is colorectal carcinoma.