PPARGC1A and osteoporosis: Remarkably, we have also described that the intake of this natural mineral-rich water induces signaling through Sirt1/p-AMPK/PGC1α in male and ovariectomized female CD Sprague Dawley rats, fructose-fed or not [28,42,43], which has a beneficial impact upon bone and cartilage and protects against osteoporosis [53,54].