Indeed, augmented tissue damage and signs of autoimmunity in the absence of TRAIL were observed, for example, following influenza [22], MCMV [177], rhinovirus [120], Listeria monocytogenes [33], and Streptococcus pneumoniae [31] infections and during sepsis induced by bacteria [32,34] or TLR-ligands [39]. Here, TNFSF10 is linked to Sepsis.