TNFSF10 and neoplasm: The tumor can achieve this by means that are not unique to TRAIL/DRs, like the upregulation of anti-apoptotic molecules [293] or an interference with general aspects of the death-receptor signaling, e.g., by mutating the death domain (DD) [294], by inactivating caspase-8 [295,296], or by overexpressing c-FLIP [297,298].