IGFBP3 and type 1 diabetes mellitus: It has been demonstrated that, especially during puberty, patients with T1DM present some alterations in the GH/IGF-1 axis, characterized by GH hypersecretion, a reduction in IGF-1 and IGFBP-3 serum, and an increase in IGFPB-1 levels [8,15,16,17,18,19,20,21,22,23,24,25].