We herein designed and synthesized benzyl esters of different triterpenes (PT1–PT6) and the newly substituted benzyl esters of gypsogenin (GP1–GP5), based on our finding that 1c (benzyl ester of gypsogenin) has anti-ABL kinase and anti-CML activities [36]. The gene discussed is GP5; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.