The role of oxylipins is far from being known in IBD, but many essential functions have been described, such as the ability to recruit neutrophils, potent chemotactic action (leukotriene B4: LTB4), platelet aggregation, increasing vascular permeability, and inducing epithelial proliferation after mucosal damage (prostaglandin E2 (PGE2), edema, and the release of pro-inflammatory cytokines such as TNFα, interleukin IL-1β, IL-6, and IL-8 [4,38,39]. Here, TNF is linked to inflammatory bowel disease.