For examples, common side effects of OCPs can include headache, mood changes, and weight gain.[23] Clomiphene citrate, a selective estrogen-receptor modulator, can make side effects such as abdominal pain or discomfort, nausea, headache, hot flashes, and mood swings.[24] As a result, complementary and alternative medicine treatments, such as acupuncture, moxibustion, and herbal medicine are attracting attention as an alternative treatment. Here, ESR1 is linked to Headache.