IL6 and chronic kidney disease: In another study, the presence of the IL-6 (−174) G allele was associated with higher IL-6 protein levels in comparison with those obtained with the C allele.[20] The IL-6 (−572) SNP was proven to be associated with several diseases by significantly increasing IL-6 expression, such as chronic kidney disease,[21] acute coronary syndrome,[22] and cerebral infarction.[23]