NFIX and Malan overgrowth syndrome: To date, together with the present study, 35 patients were described with Malan syndrome phenotype, all of them presenting deletions involving NFIX gene, with variable breakpoints (Auvin et al., 2009; Bonaglia et al., 2010; Dolan et al., 2010; Dong et al., 2016; Hino‐Fukuyo et al., 2015; Jezela‐Stanek et al., 2016; Jorge et al., 2015; Karmarkar et al., 2014; Klaassens et al., 2015; Kuroda et al., 2017; Lyon et al., 2015; Lysy et al., 2009; Malan et al., 2010; Natiq et al., 2014; Nimmakayalu et al., 2013; Priolo et al., 2018; Shimojima et al., 2015; Welham et al., 2015) (Figure 2).