Third, it is unfortunate that the pooled analyses of several clinicopathological features in this meta-analysis based on fewer than three studies, leading to an error or inaccurate conclusion in pooled results for the association between MGMT hypermethylation and these clinicopathological features including HPV infection, therapeutic response, age at diagnose and lymph node metastasis. Here, MGMT is linked to metastatic malignant neoplasm in the lymph nodes.