This analysis demonstrated that women who were positive for malaria at Visit 1 had significantly altered kinetics of the inflammatory markers, including CRP (χ2 = 99.0, p < 0.001), CHI3L1 (χ2 = 21.9, p < 0.001), IL18-BP (χ2 = 44.7, p < 0.001), sICAM-1 (χ2 = 40.8, p < 0.001), and sTNFRII (χ2 = 209.2, p < 0.001; Fig 3, Table 4; S4 and S6 Tables) over the course of pregnancy compared with women who were malaria negative at Visit 1. This evidence concerns the gene IL18 and malaria.