APOJ was highly up‐regulated in colon cancer and played oncogenic roles in multistage colorectal tumorigenesis, progression,97 and poor outcome.98 The level of APOJ in serum was significantly increased in colorectal carcinoma and could be used as a prediagnostic marker.99 The increased level of dissociative APOJ in highly aggressive tumors and metastatic nodes might be a predictive and prognostic marker for colon cancer aggressiveness.100. This evidence concerns the gene CLU and colorectal carcinoma.