APOH is a multifunctional apolipoprotein encoded by the human APOH gene and one of its functions is to bind cardiolipin.75 APOH was highly overexpressed in hepatitis B‐related HCC tissue,76 significantly upregulated in the urine of renal carcinoma patients compared with healthy controls,77 and APOH expression was significantly increased in leukemia.78 This evidence concerns the gene APOH and hepatocellular carcinoma.