The expressions of APOC1 mRNA and protein were upregulated in prostate cancer tissues and the serum levels of APOC1 were increased in prostate cancer patients.41 The mRNA and protein of APOC1 were also highly expressed in lung cancer tissues at the late stage, but no prognostic effect of serum levels of APOC1 could be found in lung cancer patients.42 This evidence concerns the gene APOC1 and Familial prostate cancer.