APOB was shown to regulate the expression of many genes in development of HCC and was related to poor prognosis in HCC patients.36 Low expression of APOB was related to the increase of metastatic and oncogenic regulators in HCC, such as FOXM1, MTIF, HGF, CD44, and ERBB2, and suppression of tumor suppressors, such as PTEN and TP53. The gene discussed is CD44; the disease is hepatocellular carcinoma.