CLU and ovarian cancer: Overexpression of APOJ in ovarian cancer could be diagnostic101 and predictive of adverse outcomes.102 Levels of APOJ in plasma of ovarian cancer patients were abnormally elevated and might be used for early diagnosis of epithelial ovarian cancer.103 APOJ was significantly overexpressed in breast carcinoma104 and could be used as a prognostic factor,105 while blocking APOJ expression could inhibit the invasion and metastasis of human breast cancer cell lines.106