In contrast, APOM mRNA and protein expression in HCC tissues were dramatically decreased compared to adjacent healthy tissues.85 Overexpression of APOM inhibited the proliferation, migration, and invasion of hepatoma cells and the development of xenograft tumors in nude mice, and promoted apoptosis.86 APOM mRNA and protein levels were notably reduced in colorectal cancer tissues, compared to adjacent healthy tissues, normal mucosa, polyps, and inflammatory mucosa.87 Here, APOM is linked to hepatocellular carcinoma.