The level of APOA2 in serum was dramatically reduced in patients with gastric cancer and multiple myeloma,29, 30 but increased in HCC and prostate cancer.31, 32 APOA2 was highly overexpressed in the cerebrospinal fluid of patients with pediatric brain tumor.33 Expression of APOA2 was significantly reduced in pancreatic cancer and APOA2 might be used as an early diagnostic marker and risk factor for it.34 The gene discussed is APOA2; the disease is AL amyloidosis.