APOJ expression was significantly upregulated in RCC tissues and could be an independent prognostic factor.107 APOJ overexpression in gastric cancer was associated with tumor progression and metastasis108 and in pancreatic carcinoma with lymph node metastasis.109 However, cytoplasmic APOJ expression was related to longer survival in NSCLC patients after surgery.110. Here, CLU is linked to metastatic malignant neoplasm in the lymph nodes.