APOA1 and hepatocellular carcinoma: APOA1 itself could also exert a suppressive effect on ovarian cancer.23 APOA1 might promote apoptosis and inhibit HCC cell proliferation by arresting the cell cycle via down‐regulation of the MAPK (mitogen‐activated protein kinase) pathway.15 APOA1 could suppress growth and metastasis of melanoma in vivo through both innate and adaptive immune pathways, but there were no significant direct suppressive effects by APOA1 on melanoma cells.27 Treatment with APOA1 mimetic peptides improved the phenotypic, inflammatory, and histopathological manifestations of colitis‐propelled carcinogenesis.28