APOE participated in the transport of lipids to glioblastoma cells and in the recycling of lipids in necrotic areas by macrophages.72 Activation of APOE restricted the innate immune system's suppression of cancer cell proliferation, thus promoting tumor growth and metastasis in many types of cancers.73 APOE was regulated by various miRNAs and increased LRP1/LRP8‐dependent melanoma metastasis and angiogenesis.74 This evidence concerns the gene LRP8 and cancer.