APOE and Familial prostate cancer: APOE was overexpressed in various ovarian cell lines and tissues and it was essential for growth and survival of ovarian cancer cells.63 The level of APOE in the serum of patients with ovarian cancer was dramatically increased over healthy individuals and as a marker, it could enhance the specificity and sensitivity of ovarian cancer diagnosis.64 APOE was highly expressed in the PC‐3 human prostate cancer cell line and its expression was directly correlated with the Gleason score of prostate cancer tissues, hormone independence and local and distant metastasis.65