CASP8 and melanoma: After 48 h melanoma cells in the presence of 2155–14 alone or in combination with the pan-caspase inhibitor, caspase 8 inhibitor, or and calpain I selective inhibitor were 0%, 20%, 25% and 50% viable, respectively, suggesting that viability cannot be completely rescued by the inhibition of caspases and calpains (Fig. 12F and G).