NECTIN4 and breast carcinoma: Most recently, M-Rabet et al. performed a mRNA- and protein-based analysis of Nectin-4 expression in approximately 5,700 invasive breast cancer samples, showing that Nectin-4 is significantly overexpressed in both triple negative and basal breast cancer samples, with high expression of mRNA being an independent biomarker associated with poor prognosis in TNBC (21).