Most recently, M-Rabet et al. performed a mRNA- and protein-based analysis of Nectin-4 expression in approximately 5,700 invasive breast cancer samples, showing that Nectin-4 is significantly overexpressed in both triple negative and basal breast cancer samples, with high expression of mRNA being an independent biomarker associated with poor prognosis in TNBC (21). The gene discussed is NECTIN4; the disease is breast cancer.