Through competitively binding to hsa-miR-29b, hsa-miR-101 and hsa-miR-15a, the expressional perturbation of KIAA1586 and the resultant changes in KIAA1586-associated ceRNA crosstalk interactions cause the abnormalities of AD-associated biological processes and contribute to the risk of AD (Figure 4). The gene discussed is KIAA1586; the disease is Alzheimer disease.