LOX and neoplasm: Inflammation involves high ECM remodeling with large ECM protein deposition, which are crosslinked by increased levels of lysyl oxidase (LOX) (Barker et al., 2012), contributing to solid stresses (Kalli and Stylianopoulos, 2018), tumor ECM stiffening (Gkretsi and Stylianopoulos, 2018), and drug resistance (Erler et al., 2006).