Lastly, salivary levels of IL-6, IL-8, IL-10, and TNFα are all increased in patients with malignant OSCC and thus are proposed to be discriminative biomarkers for oral cancer with IL-6 being associated with poor response to therapy and poor prognosis (14, 16, 18, 22–24). This evidence concerns the gene IL6 and lip and oral cavity carcinoma.