The analysis of correlation between KLK5 expression and prognosis indicated that higher KLK5 mRNA level could sever as indicator for predicting unfavorable prognosis in ovarian cancer patients (25, 26) and breast cancer patients (28) and sever as indicator for predicting favorable prognosis in prostate cancer patients (27) and testicular cancer patients (39). This evidence concerns the gene KLK5 and prostate cancer.