Using chromatin fractionation, although not exclusively for ANRIL Ray et al. (28) found a number of lncRNAs involved in PcG biology to be primarily localized to the nucleus (28), and in a second study nuclear extracts of prostate cancer cells showed ANRIL association with CBX7 protein a member of the PRC1 complex (5). The gene discussed is CBX7; the disease is Familial prostate cancer.