Moreover, it has been reported that PD-L1 was predominantly expressed in the lymphoepithelioma-like subtype of HCC (LEL-HCC), which is characterized by sheets of neoplastic cells intermingled with a dense immune stroma made of cytotoxic T (CD8+) cells (20, 32, 33). The gene discussed is CD274; the disease is nasopharyngeal type undifferentiated carcinoma.