CDKN2A and acute lymphoblastic leukemia: In the 27 T-ALL cases (18% of total ALL cases), deletions were noted in 59% (n = 16) cases primarily in the CDKN2A/B gene locus followed by MTAP (~33%), 15% in MLLT3/ PTEN/ JAK2, and <10% in PAR1, IKZF1, EZH2, EBF1, and PHF6 (Figure 2A; Supplementary Table S1).