The specific genetic subtypes in B-ALL are associated with distinct prognostic outcomes e.g., t(9;22) BCR-ABL1 translocation, MLL gene rearrangements, hypodiploidy, and intrachromosomal amplification of chromosome 21 (iAMP21) predict poor outcome and genetic hallmarks such as ETV6-RUNX1 and hyperdiploid ALL predict favorable outcome (1, 5). The gene discussed is KMT2A; the disease is acute lymphoblastic leukemia.