Especially, the mRNA expression levels of SIRT1 were significantly downregulated in patients with OC in Bonome’s dataset (Bonome et al., 2008) with a log2 fold change of −1.866, while SIRT5 and SIRT7 were higher in ovarian serous adenocarcinoma in two another datasets (Yoshihara Ovarian and TCGA datasets; log2 fold changes, 1.929 and 1.626, respectively) (Yoshihara et al., 2009) than in normal ovarian tissues (Table 1, bold font). This evidence concerns the gene SIRT5 and ovarian serous adenocarcinoma.