c-MYC is a crucial oncogenic transcription factor that is highly expressed in basal-like breast cancer (Chen and Olopade, 2008), and Notch signaling, an evolutionarily conserved cell fate determination pathway, is involved in multiple aspects of tumor biology, from angiogenesis to cancer stem cell maintenance to tumor immunity (Espinoza and Miele, 2013). The gene discussed is MYC; the disease is breast carcinoma.