SMUG1 and neoplasm: In addition, increased expression of SMUG1 is often found in various tumor types (including bladder, gastric, breast, esophageal, and cervical cancers) with adverse clinicopathological features, such as poorly differentiated and chemoradiotherapy-resistant tumors (Abdel-Fatah et al., 2013; An et al., 2013; Korourian et al., 2017).